About: Pramocaine

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Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Pill (pharmacy) yago:WikicatAnesthetics yago:WikicatLocalAnesthetics yago:Agent114778436 yago:Anesthetic102710766 yago:CausalAgent100007347 yago:Drug103247620 yago:LocalAnesthetic103681148 yago:Matter100020827 yago:PhysicalEntity100001930 drug yago:Substance100020090 umbel-rc:DrugProduct
rdfs:label	Pramocaine (en) Pramocaïne (nl)
rdfs:comment	Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness. (en) Pramocaïne (ook wel pramoxine genoemd) is een geneesmiddel, gebruikt als lokaal anestheticum. Het wordt alleen toegepast in verdovende crèmes.Binnen lokale anesthetica worden amidetype en estertype middelen onderscheiden. Pramocaïne valt in geen van beide klassen. (nl)
foaf:depiction
dcterms:subject	Local anesthetics Phenol ethers Morpholines
Wikipage page ID	8981015 (xsd:integer)
Wikipage revision ID	1118743242 (xsd:integer)
Link from a Wikipage to another Wikipage	Antipruritic dbr:Hydroquinone Poison ivy 1-bromobutane Local anesthetics Phenol ethers Over-the-counter drug Gold Bond Poison sumac Topical anesthetic Local anesthesia Abbott Laboratories British Approved Name Morpholines Emerods International Nonproprietary Name Hydrochloride Calamine lotion Sunburn Salt (chemistry) Neosporin Local anesthetics Poison oak
sameAs	Pramocaine Pramocaine Pramocaine Pramocaine Pramocaine Pramocaine Pramocaine Pramocaine Pramocaine
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Reflist dbt:Use_mdy_dates dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:ATC dbt:Drugs.com dbt:Antipruritics dbt:Vasoprotectives
thumbnail	wiki-commons:Special:FilePath/Pramoxine.svg?width=300
ATC suffix	AB07 (en)
ATC prefix	D04 (en)
c	17 (xsd:integer)
CAS number	140 (xsd:integer) 637 (xsd:integer)
ChEBI	8357 (xsd:integer)
ChEMBL	1198 (xsd:integer)
ChemSpiderID	4717 (xsd:integer)
H	27 (xsd:integer)
index2 label	hydrochloride (en)
IUPAC name	4 (xsd:integer)
legal status	Depends on country, some formulations OTC others Rx only (en)
MedlinePlus	a682429 (en)
n	1 (xsd:integer)
O	3 (xsd:integer)
PubChem	4886 (xsd:integer)
routes of administration	Topical, rectal, Vaginal (en)
SMILES	OCCCC (en)
StdInChI	1 (xsd:integer)
StdInChIKey	DQKXQSGTHWVTAD-UHFFFAOYSA-N (en)
UNII	68 (xsd:integer) 88 (xsd:integer)
Verifiedfields	changed (en)
verifiedrevid	464213174 (xsd:integer)
Watchedfields	changed (en)
has abstract	Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness. (en)

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