The 2021 Arizona Wildcats football team represented the University of Arizona during the 2021 NCAA Division I FBS football season. They were led by first-year head coach Jedd Fisch, and they played their home games at Arizona Stadium in Tucson, Arizona. It was the Wildcats' 122nd season overall and 43rd as a member of the Pac-12 Conference and 11th in the Pac-12 South Division.