William Henry Sharpe (April 19, 1868 – April 19, 1942) was a Canadian merchant and political figure in Manitoba, Canada. He represented Lisgar in the House of Commons of Canada from 1908 to 1915 as a Conservative. Sharpe sat for Manitou division in the Senate of Canada from 1916 to 1942. His brother Samuel Simpson Sharpe also served in the House of Commons.