The Wetherby Mares' Hurdle is a Listed National Hunt horse race in Great Britain which is open to mares aged four years or older. It is run at Wetherby over a distance of about 2 miles (3,219 metres), and during its running there are nine hurdles to be jumped. The race is scheduled to take place each year in late October or early November. From 2012 to 2018 OLBG were the race sponsors. It returned to the 2 miles distance from 2015. Bet365 resumed sponsorship from the 2019 running and the race is now titled the bet365 Mares' Hurdle.