Water polo competitions at the 2022 South American Games in Asuncion, Paraguay were held from 11 to 15 October 2022 at the Centro Acuático Nacional cluster. Two medal events were scheduled to be contested: a men's and women's tournament. A total of 168 athletes (78 athletes–6 teams for men and 91 athletes–7 teams for women) competed in the events. Both tournaments were open competitions without age restrictions. Brazil won the gold medal in both men's and women's events.