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About: Ventilation-perfusion coupling     Goto   Sponge   NotDistinct   Permalink

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Ventilation-perfusion coupling is the relationship between ventilation and perfusion processes, which take place in the respiratory and cardiovascular systems. Ventilation is the movement of gas during breathing, and perfusion is the process of pulmonary blood circulation, which delivers oxygen to body tissues. Anatomically, the lung structure, alveolar organization, and alveolar capillaries contribute to the physiological mechanism of ventilation and perfusion. Ventilation-perfusion coupling maintains a constant ratio near 0.8 on average, while the regional variation exists within the lungs due to gravity. When the ratio gets above or below 0.8, it is considered abnormal ventilation-perfusion coupling, also known as a ventilation-perfusion mismatch. Lung diseases, cardiac shunts, and smok