The Umfolozi River (also uMfolozi, Imfolozi or Mfolozi) is a river in KwaZulu-Natal, a province of South Africa. It is formed by the confluence of the Black (Imfolozi emnyama) and White Umfolozi (Imfolozi emhlope) Rivers near the southeastern boundary of the Hluhluwe-Umfolozi Game Reserve. The isiZulu name imFolozi is generally considered to describe the zigzag course followed by both tributaries, though other explanations have been given.