USS Santiago de Cuba was a side-wheel steamship acquired by the Union Navy during the first year of the American Civil War. She was outfitted as a gunboat with powerful 20-pounder rifled guns and 32-pounder cannon and was assigned to the Union blockade of the Confederate States of America. She was notably successful in this role, capturing several blockade runners. Her last major action of the war was the assault on Fort Fisher, during which seven of her crew won the Medal of Honor.