U.S. Route 167 runs for 500 miles (800 km) from Ash Flat, Arkansas at U.S. Route 62/US Route 412 to Abbeville, Louisiana at Louisiana Highway 14. It goes through the cities of Little Rock, Arkansas, Alexandria, Louisiana, and Lafayette, Louisiana. Some of the highway's route has been combined with or parallels Interstate 49 in Louisiana. Between Junction City, Arkansas, and Ruston, Louisiana, U.S. 167 runs concurrent with U.S. 63.