The Tiguex War was the first named war between Europeans and Native Americans in what is now part of the United States. The war took place in New Spain, during the exploration of Nuevo México prior to settlement. It was fought in the winter of 1540-41 by the expedition of Francisco Vázquez de Coronado against the twelve or thirteen Pueblos of what would become the Tiguex Province of Nuevo México. These villages were along both sides of the Rio Grande, north and south of present-day Bernalillo, New Mexico.