Thomas Wilson Spence (September 2, 1846 – February 23, 1912) was an Irish American immigrant, lawyer, and politician. He was a member of the Wisconsin State Assembly, representing the city of Fond du Lac during the 1877 and 1879 sessions. As a young man, he was one of the "Ohio Five", who were among the early students of Cornell University. Spence rose to legal prominence in Milwaukee, and died of a heart attack in the chambers of the Wisconsin Supreme Court while making oral arguments. "He died with his tie on."