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About: Thomas J. Silhavy     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Whole100003553, within Data Space : dbpedia.org associated with source document(s)

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Thomas J. Silhavy is the Warner-Lambert Parke-Davis Professor of molecular biology at Princeton University. Silhavy is a bacterial geneticist who has made fundamental contributions to several different research fields. He is best known for his work on protein secretion, membrane biogenesis, and signal transduction. Using Escherichia coli as a model system, his lab was the first to isolate signal sequence mutations, identify a component of cellular protein secretion machinery, discover an integral membrane component of the outer membrane assembly machinery, and to identify and characterize a two-component regulatory system. Current work in his lab is focused on the mechanisms of outer membrane biogenesis and the regulatory systems that sense and respond to envelope stress and trigger the de