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About: T-cell receptor excision circles     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatTCells, within Data Space : dbpedia.org associated with source document(s)

Type: yago:Abstraction100002137yago:AmorphousShape113867492yago:Attribute100024264yago:Cell102991711yago:Compartment103080309yago:Location100027167yago:Object100002684yago:PhysicalEntity100001930yago:YagoGeoEntityyago:YagoLegalActorGeoyago:YagoPermanentlyLocatedEntityhistoric placeyago:Shape100027807yago:Space113910384yago:WikicatTCells New Facet based on Instances of this Class

T-cell receptor excision circles (TRECs) are small circles of DNA created in T-cells during their passage through the thymus as they rearrange their TCR genes. Their presence indicates maturation of T cells;TRECs are reduced in SCID (Severe combined immunodeficiency disease). Signal joint T-cell receptor excision circles (sjTRECs) might be used as a way to test the age of the individual from a blood sample. The detection of sjTRECs can be further used as a diagnostic tool to monitor the thymic output (e.g., following hematopoietic stem cell transplantation or in cases of AIDS).