The Southern Ohio Lunatic Asylum is an historic structure at 2335 Wayne Ave. in Dayton, Ohio. It was added to the National Register of Historic Places on November 15, 1979. The 300-acre (120 ha) complex was designed as a mental asylum in accordance with principles advocated by Philadelphia psychiatrist Thomas Story Kirkbride in the mid-19th century. It was renamed the Dayton State Hospital and later the Dayton Mental Health Center.
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