Simisani Mathumo (born 11 November 1991) is a Motswana footballer who plays for Botola side Olympique Khouribga and the Botswana national football team. Simisani began his football career in the Township Rollers academy in 2005. He was given his first senior appearance by then manager Madinda Ndlovu as a sixteen year old. After impressing Simisani would go on to become a mainstay in the Rollers defence, playing for them over twelve years and winning all of the cups on offer including six Premier Leagues, one FA Cup and two Mascom Top 8 Cups. He left Rollers in 2019 to join South African side Free State Stars but his contract was terminated after the club was relegated from the Absa Premiership and he returned to Rollers.