Sespe Creek (Chumash: S'eqp'e', "Kneecap") is a stream, some 61 miles (98 km) long, in Ventura County, southern California, in the Western United States. The creek starts at Potrero Seco in the eastern Sierra Madre Mountains, and is formed by more than thirty tributary streams of the Sierra Madre and Topatopa Mountains, before it empties into the Santa Clara River in Fillmore.