Sekolah Menengah Sains Rembau (English: Rembau Science Secondary School; abbreviated SEMESRA) is a co-educational secondary school situated in the district of Rembau and among fully residential schools (Sekolah Berasrama Penuh) in the state of Negeri Sembilan, Malaysia. Established in 2009, the school is widely known as SEMESRA. In the recent PMR examination (2013), the school managed to produce 108 straight A's students with GPS 1.0535 to become the third best school in Negeri Sembilan.