About: SKF-82,958

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SKF-82,958 is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist. SKF-82,958 and similar D1-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine. SKF-82,958 was also subsequently found to act as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen.

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rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:AliphaticCompound114601294 yago:Alkene114713120 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:Relation100031921 chemical compound drug yago:Statement106722453 yago:Substance100019613 yago:WikicatAlkenes yago:WikicatPhenols
rdfs:label	SKF-82,958 (en)
rdfs:comment	SKF-82,958 is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist. SKF-82,958 and similar D1-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine. SKF-82,958 was also subsequently found to act as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen. (en)
foaf:depiction
dcterms:subject	D5 receptor agonists Allyl compounds Chloroarenes GSK plc brands Phenols Synthetic estrogens 1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines D1-receptor agonists
Wikipage page ID	3848593 (xsd:integer)
Wikipage revision ID	1115659615 (xsd:integer)
Link from a Wikipage to another Wikipage	Benzazepine Anorectic D5 receptor agonists Dopaminergic Allyl compounds Chloroarenes GSK plc brands Phenols Synthetic estrogens SKF-81,297 Chemical compound Chemical synthesis Estrogen Full agonist Stimulant 1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines D1-receptor agonists 6-Br-APB Agonist Amphetamine D1 receptor D5 receptor Hyperactivity Self-administration Chemical class ERα ERβ
sameAs	SKF-82,958 SKF-82,958 SKF-82,958 SKF-82,958 SKF-82,958 SKF-82,958
dbp:wikiPageUsesTemplate	dbt:Gastrointestinal-drug-stub dbt:Drugbox dbt:Estrogen_receptor_modulators dbt:Reflist dbt:Short_description dbt:Stimulants dbt:Fdacite dbt:Dopamine_receptor_modulators dbt:Anorectics
thumbnail	wiki-commons:Special:FilePath/SKF_82958.png?width=300
c	19 (xsd:integer)
CAS number	80751 (xsd:integer)
ChEMBL	317741 (xsd:integer)
ChemSpiderID	1188 (xsd:integer)
Cl	1 (xsd:integer)
H	20 (xsd:integer)
IUPAC name	3 (xsd:integer)
n	1 (xsd:integer)
O	2 (xsd:integer)
PubChem	1225 (xsd:integer)
SMILES	C=CCN1CCC2=CCl (en)
UNII	7 (xsd:integer)
has abstract	SKF-82,958 is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist. SKF-82,958 and similar D1-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine. SKF-82,958 was also subsequently found to act as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen. (en)
gold:hypernym	Compound
prov:wasDerivedFrom	wikipedia-en:SKF-82,958?oldid=1115659615&ns=0
page length (characters) of wiki page	6650 (xsd:nonNegativeInteger)
CAS number	80751-65-1

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