Artasalvin, otherwise 22-thiocyanatosalvinorin A (previously known as RB-64) is a semi-synthetic salvinorin derivative and a κ-opioid receptor (KOR) agonist which is used in scientific research. Its most remarkable property is its biased activity in signal transduction in favour of G protein versus β-arrestin-2, a phenomenon which is called functional selectivity or biased agonism. Artasalvin has a bias factor of 96 and is analgesic with fewer of the prototypical side-effects associated with unbiased KOR agonists. The analgesia-like effect is long-lasting. Compared with unbiased agonists artasalvin evokes considerably less receptor internalisation.
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| - Artasalvin, otherwise 22-thiocyanatosalvinorin A (previously known as RB-64) is a semi-synthetic salvinorin derivative and a κ-opioid receptor (KOR) agonist which is used in scientific research. Its most remarkable property is its biased activity in signal transduction in favour of G protein versus β-arrestin-2, a phenomenon which is called functional selectivity or biased agonism. Artasalvin has a bias factor of 96 and is analgesic with fewer of the prototypical side-effects associated with unbiased KOR agonists. The analgesia-like effect is long-lasting. Compared with unbiased agonists artasalvin evokes considerably less receptor internalisation. (en)
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| - Methyl -2--6a,10b-dimethyl-4,10-dioxo-9-oxy-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromene-7-carboxylate (en)
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| - C[C@@]12CC[C@H]3CO[C@@H]C4=COC=C4 (en)
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| - AZPUAKGNQXURGA-ZWLNRFIDSA-N (en)
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| - Artasalvin, otherwise 22-thiocyanatosalvinorin A (previously known as RB-64) is a semi-synthetic salvinorin derivative and a κ-opioid receptor (KOR) agonist which is used in scientific research. Its most remarkable property is its biased activity in signal transduction in favour of G protein versus β-arrestin-2, a phenomenon which is called functional selectivity or biased agonism. Artasalvin has a bias factor of 96 and is analgesic with fewer of the prototypical side-effects associated with unbiased KOR agonists. The analgesia-like effect is long-lasting. Compared with unbiased agonists artasalvin evokes considerably less receptor internalisation. (en)
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