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About: PrfA thermoregulator UTR     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:PsychologicalFeature100023100, within Data Space : dbpedia.org associated with source document(s)

Type: yago:WikicatCis-regulatoryRNAElementsyago:Abstraction100002137yago:Cognition100023271yago:Component105868954yago:Concept105835747yago:Content105809192yago:Idea105833840yago:Part105867413yago:PsychologicalFeature100023100 New Facet based on Instances of this Class

The PrfA thermoregulator UTR is an RNA thermometer found in the 5' UTR of the prfA gene. In Listeria monocytogenes, virulence genes are maximally expressed at 37 °C (human body temperature) but are almost silent at 30 °C. The genes are controlled by , a transcriptional activator whose expression is thermoregulated. It has been shown that the untranslated mRNA (UTR) preceding prfA, forms a secondary structure, which masks the ribosome binding region. It is thought that at 37 °C, the hairpin structure 'melts' and the SD sequence is unmasked.