Pennsylvania Route 981 (PA 981) is a state highway which runs 50.4 miles (81.1 km) across Westmoreland County, in southwestern Pennsylvania, United States. The highway begins at PA 51 in Rostraver Township, Pennsylvania, and runs northward across Westmoreland County, passing through the towns of Mount Pleasant, Latrobe, and New Alexandria before ending at PA 819 in Salina.