Pennsylvania Route 655 (PA 655) is an 83-mile-long (134 km) north–south state highway located in central Pennsylvania. The southern terminus of the route is at the Mason–Dixon line in Thompson Township, where the road becomes a local road (North Pennsylvania Avenue) in Hancock, Maryland. The northern terminus is at State Route 1005 (SR 1005), the former alignment of U.S. Route 322 (US 322), in Reedsville.