Panagiotis Demestichas (Greek: Παναγιώτης Δεμέστιχας, 6 July 1885 (O.S.) – 14 November 1960) was an officer of the Greek Army who rose to the rank of Lieutenant General, leading an army corps in the Greco-Italian War. He also briefly served as Minister of the Interior in the first collaborationist government under general Georgios Tsolakoglou during the Axis occupation of Greece.