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About: dbr:P53     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatProteins, within Data Space : dbpedia.org associated with source document(s)

Type: ThingBiomoleculegeneBiomoleculeGeneyago:WikicatTranscriptionFactorsyago:WikicatTumorSuppressorGenesyago:Abstraction100002137yago:Arrangement107938773yago:Beginning107290905yago:Cause107326557yago:Chemical114806838yago:Compound114818238yago:Event100029378yago:Factor107327805yago:Gene105436752yago:Group100031264yago:Happening107283608yago:Macromolecule114944888yago:Material114580897yago:Matter100020827yago:Molecule114682133yago:Ordering108456993yago:OrganicCompound114727670yago:Origin107323922yago:Part113809207yago:PhysicalEntity100001930yago:Protein114728724yago:PsychologicalFeature100023100yago:Relation100031921yago:WikicatGenesyago:WikicatGenesMutatedInMiceyago:WikicatGenesOnChromosome17yago:WikicatHumanProteinsyago:YagoPermanentlyLocatedEntityHumanGeneyago:Sequence108459252yago:Series108457976yago:Substance100019613yago:Suppressor105441468yago:Thing100002452yago:TumorSuppressorGene105441806yago:Unit109465459yago:WikicatAging-relatedGenesyago:WikicatAging-relatedProteinsyago:WikicatProteins New Facet based on Instances of this Class

p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.