The Osterville Baptist Church is an historic Baptist church building at 824 Main Street in the Osterville village of Barnstable, Massachusetts. The white clapboarded wood-frame structure was built in 1837 for a congregation formed two years earlier. It is one of the older buildings in Osterville, and is a fine example of the Greek Revival with Gothic Revival elements. The church was listed on the National Register of Historic Places in 1987.