Husam ad-Din Muhanna ibn Isa (also known as Muhanna II; d. 1335) was the Arab lord of Palmyra and amir al-ʿarab (commander of the Bedouins) under the Mamluk Sultanate. He served between 1284 and his death, but was dismissed and reinstated four times during this period. As the chieftain of the Al Fadl, a clan of the Tayy tribe, which dominated the Syrian Desert, Muhanna wielded considerable influence among the Bedouin. He was described by historian Amalia Levanoni as "the eldest and most senior amir" of the Al Fadl during his era.