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Microfold cells (or M cells) are found in the gut-associated lymphoid tissue (GALT) of the Peyer's patches in the small intestine, and in the mucosa-associated lymphoid tissue (MALT) of other parts of the gastrointestinal tract. These cells are known to initiate mucosal immunity responses on the apical membrane of the M cells and allow for transport of microbes and particles across the epithelial cell layer from the gut lumen to the lamina propria where interactions with immune cells can take place.

AttributesValues
rdf:type
rdfs:label
  • M-Zelle (de)
  • Sel M (in)
  • Cellula M (it)
  • Cellule M (fr)
  • M細胞 (ja)
  • Microfold cell (en)
  • Célula M (pt)
  • 微皱褶细胞 (zh)
rdfs:comment
  • Bei M-Zellen (M engl. für microfold; fold = „Falte“, micro = „klein“) handelt es sich um spezialisierte Epithelzellen, die in der Wand des Krummdarms (Ileum), einem Teil des Dünndarms, und den Tonsillen vorkommen. Sie spielen eine wichtige Rolle für die Funktion des Immunsystems. (de)
  • M細胞（えむさいぼう）または小襞細胞（英:microfold cell, M cell）とは、パイエル板を覆うの吸収上皮細胞間に散在する細胞である。膜状の微絨毛を有する。M細胞において細菌やウイルスの取り込みが観察されていることから、M細胞は消化管の免疫に関与していると考えられている。なお、赤痢菌は、このM細胞に侵入することが知られている。 (ja)
  • As células M (M de microfold, microprega em inglês) ou células microfenestradas são enterócitos modificados localizados no tecido linfoide associado à mucosa e nas placas de Peyer no íleo. Participam do sistema imune através do carregamento de partículas estranhas (antígenos) do lúmen intestinal até centros germinativos subjacentes. Para que ocorra esse transporte, essas células possuem micropregas na superfície apical e uma lâmina basal descontínua com invaginações em sua superfície por onde passam os antígenos. Essas características diferenciam as células M do restante do epitélio intestinal, já que os enterócitos apresentam em sua superfície microvilosidades. (pt)
  • 微皱褶细胞(Microfold cells)是一种免疫细胞。分布于胃肠道、口腔部（例如扁桃体）、小型唾液腺管、呼吸道、眼角膜、生殖泌尿道等部位。 (zh)
  • Microfold cells (or M cells) are found in the gut-associated lymphoid tissue (GALT) of the Peyer's patches in the small intestine, and in the mucosa-associated lymphoid tissue (MALT) of other parts of the gastrointestinal tract. These cells are known to initiate mucosal immunity responses on the apical membrane of the M cells and allow for transport of microbes and particles across the epithelial cell layer from the gut lumen to the lamina propria where interactions with immune cells can take place. (en)
  • Sel M (bahasa Inggris: microfold cell, M cell) adalah sel yang ditemukan pada epitelium folikel dari Peyer's patch, sebuah jaringan limfatik yang disebut (bahasa Inggris: gut-associated lymphoid tissue). Sel M mengusung organisme dan partikel dari dinding usus menuju sel-sel yang berperan sistem kekebalan. Sel M memiliki kemampuan fagositosis maupun pinositosis dan mengirim apa yang ditelannya melalui proses kepada sel dendritik dan sel T. Sel M dapat menjadi perantara infeksi HIV. (in)
  • Le cellule M sono una sottopopolazione del MALT (Tessuto Linfoide Associato alle Mucose). Sono cellule altamente specializzate, e costituiscono il 10% delle cellule mucosali dell'intestino. Risultano difficili da studiare e sono state isolate solo recentemente. Differiscono dalle circostanti cellule mucosali per la loro forma, sono difatti molto assottigliate, membranose (da qui il nome Cellule M, membranose appunto).Sono situate nei tratti sovrastanti noduli linfatici detti Placche di Peyer (localizzate nella sottomucosa). (it)
  • Les cellules M (ou Microfold cells, qui se traduit par cellules à plis microscopiques) font partie du tissu lymphoïde associé au tube digestif (GALT), à savoir les plaques de Peyer de l'intestin grêle et du tissu lymphoïde associé aux muqueuses (MALT) dans d'autres parties du tractus gastro-intestinal. Ces cellules sont connues pour initier des réponses du système immunitaire des muqueuses sur la membrane apicale des cellules M et permettre le transport de microbes et de particules à travers la paroi intestinale, les captant dans la lumière intestinale pour les mener jusqu'à la lamina propria où des interactions avec les cellules immunitaires peuvent avoir lieu. (fr)
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  • Microfold cell (en)
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