Mendocino Lumber Company operated a sawmill on Big River near the town of Mendocino, California. The sawmill began operation in 1853 as the Redwood Lumber Manufacturing Company, and changed ownership several times before cutting its final logs in 1938. The sawmill site became part of the Big River Unit of Mendocino Headlands State Park where a few features of the mill and its associated forest railway are still visible along the longest undeveloped estuary in northern California.