Mary Holloway Wilhite (née , Holloway; February 3, 1831 – February 8, 1892) was a 19th-century American physician and philanthropist. She was the first female medical graduate from Indiana, as well as the first female practitioner in the state. Wilhite made several important discoveries regarding the effects of medical pharmaceuticals in certain diseases. Her greatest success was in the treatment of women and children. A woman's suffrage and women's rights leader, she was also the founder of the Montgomery County, Indiana Orphans' home. Wilhite contributed regularly to the local newspapers.