Louisiana Highway 101 (LA 101) is a state highway located in southwestern Louisiana. It runs 17.28 miles (27.81 km) in a general north–south direction from LA 14 in Hayes to LA 383 north of Iowa. An entirely rural route traveling midway between the cities of Lake Charles and Jennings, LA 101 intersects three major highways: U.S. Highway 90 (US 90), Interstate 10 (I-10), and US 165. The majority of the route, running from the southern terminus across I-10, is bannered north–south. The remainder of the route on either side of US 165 runs east–west and is bannered accordingly.