About: Loop modeling

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Loop modeling is a problem in protein structure prediction requiring the prediction of the conformations of loop regions in proteins with or without the use of a structural template. Computer programs that solve these problems have been used to research a broad range of scientific topics from ADP to breast cancer. Because protein function is determined by its shape and the physiochemical properties of its exposed surface, it is important to create an accurate model for protein/ligand interaction studies. The problem arises often in homology modeling, where the tertiary structure of an amino acid sequence is predicted based on a sequence alignment to a template, or a second sequence whose structure is known. Because loops have highly variable sequences even within a given structural motif o

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rdf:type	yago:Ability105616246 yago:Abstraction100002137 yago:Cognition100023271 yago:Know-how105616786 yago:Method105660268 yago:PsychologicalFeature100023100 disease yago:WikicatProteinMethods
rdfs:label	Loop modeling (en)
rdfs:comment	Loop modeling is a problem in protein structure prediction requiring the prediction of the conformations of loop regions in proteins with or without the use of a structural template. Computer programs that solve these problems have been used to research a broad range of scientific topics from ADP to breast cancer. Because protein function is determined by its shape and the physiochemical properties of its exposed surface, it is important to create an accurate model for protein/ligand interaction studies. The problem arises often in homology modeling, where the tertiary structure of an amino acid sequence is predicted based on a sequence alignment to a template, or a second sequence whose structure is known. Because loops have highly variable sequences even within a given structural motif o (en)
dcterms:subject	Bioinformatics Protein structure Protein methods
Wikipage page ID	8865843 (xsd:integer)
Wikipage revision ID	1018829688 (xsd:integer)
Link from a Wikipage to another Wikipage	Protein Data Bank (file format) Electron density Structural motif Breast cancer De novo protein structure prediction Sequence alignment Protein structure prediction Bioinformatics Conserved sequence MODELLER Adenosine diphosphate Amino acid Protein structure Globular protein Protein folding Protein Ramachandran plot Backbone-dependent rotamer library Andrej Sali Protein methods Homology modeling Tertiary structure Dihedral angle X-ray crystallography Solvent Loop (biochemistry) Side chain Protein NMR Amino acid sequence Chemical conformation
Link from a Wikipage to an external page	http://mordred.bioc.cam.ac.uk/~rapper http://proteinformatics.charite.de/sl2 http://tanto.bioe.uic.edu/DiSGro https://web.archive.org/web/20121116010055/http:/falc-loop.seoklab.org/ http://modbase.compbio.ucsf.edu/modloop
sameAs	Loop modeling Loop modeling Loop modeling Loop modeling
dbp:wikiPageUsesTemplate	dbt:Reflist dbt:Update
has abstract	Loop modeling is a problem in protein structure prediction requiring the prediction of the conformations of loop regions in proteins with or without the use of a structural template. Computer programs that solve these problems have been used to research a broad range of scientific topics from ADP to breast cancer. Because protein function is determined by its shape and the physiochemical properties of its exposed surface, it is important to create an accurate model for protein/ligand interaction studies. The problem arises often in homology modeling, where the tertiary structure of an amino acid sequence is predicted based on a sequence alignment to a template, or a second sequence whose structure is known. Because loops have highly variable sequences even within a given structural motif or protein fold, they often correspond to unaligned regions in sequence alignments; they also tend to be located at the solvent-exposed surface of globular proteins and thus are more conformationally flexible. Consequently, they often cannot be modeled using standard homology modeling techniques. More constrained versions of loop modeling are also used in the data fitting stages of solving a protein structure by X-ray crystallography, because loops can correspond to regions of low electron density and are therefore difficult to resolve. Regions of a structural model that are predicted by non-template-based loop modeling tend to be much less accurate than regions that are predicted using template-based techniques. The extent of the inaccuracy increases with the number of amino acids in the loop. The loop amino acids' side chains dihedral angles are often approximated from a rotamer library, but can worsen the inaccuracy of side chain packing in the overall model. Andrej Sali's homology modeling suite MODELLER includes a facility explicitly designed for loop modeling by a satisfaction of spatial restraints method. All methods require an upload of the PDB file and some require the specification of the loop location. (en)
gold:hypernym	Problem
prov:wasDerivedFrom	wikipedia-en:Loop_modeling?oldid=1018829688&ns=0
page length (characters) of wiki page	9934 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Loop_modeling
is Link from a Wikipage to another Wikipage of	Rosetta@home Homology modeling Loop modelling
is Wikipage redirect of	Loop modelling
is foaf:primaryTopic of	wikipedia-en:Loop_modeling

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