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About: List of benzimidazole opioids     Goto   Sponge   NotDistinct   Permalink

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Benzimidazole opioids, also known as nitazenes, are a class of synthetic opioids with an unusual structure and often referred as opioid New Synthetic Substances (opioid NPS). First synthesized in the 1950s by CIBA Pharmaceuticals as potential analgesic medications, several substances in the class have been identified, the best known being etonitazene. Like other synthetic opioids, benzimidazole opioids bind the mu-opioid receptor and may exhibit potency up to several hundred times that of morphine. While several substances in this class have found applications in research, they have never been used in clinical medicine due to their profound risk of respiratory depression and death, and have recently been recognized as emerging drugs of abuse. Isotonitazine was first identified in samples o