James L. Antoine (born 1949) is a former politician from the Northwest Territories, Canada. He served as a member of the Legislative Assembly of the Northwest Territories from 1991 to 2003. During his time in office he led the Northwest Territories government as the eighth premier of the Northwest Territories from 1998 to 2000. He has also served as Chief of the Liidlii Kue First Nation on four occasions from the 1970s to present.