Jakob Mathias Antonson Lothe (14 November 1881 – 17 June 1975) was a Norwegian politician for the Liberal Party. He was born in Lote in Gloppen as a son of farmers Anton Jakobsen Lothe (1852–1932) and Anne Marie A. Røsæt (1853–1940). Lothe was President of the Lagting, the former quasi-upper house of the parliament of Norway, from 1945–1954.