Irene Kwambai Kipchumba (born 25 October 1978) is a Kenyan long-distance runner. Her first major medal came at the 2004 African Championships in Athletics where she took silver in the 10,000 metres behind Eyerusalem Kuma. She also won the Cursa de Bombers that year and repeated as the winner in 2005, setting a course record in the process. She ran at the 2005 World Championships in Athletics and was tenth in the women's 10,000 m. Her 2006 season was highlighted by a win at the Vitry-sur-Seine Half Marathon. She won the women's 5K race at the Prague Grand Prix the following year.