Intraflagellar transport (IFT) is a bidirectional motility along axoneme microtubules that is essential for the formation (ciliogenesis) and maintenance of most eukaryotic cilia and flagella. It is thought to be required to build all cilia that assemble within a membrane projection from the cell surface. Plasmodium falciparum cilia and the sperm flagella of Drosophila are examples of cilia that assemble in the cytoplasm and do not require IFT. The process of IFT involves movement of large protein complexes called IFT particles or trains from the cell body to the ciliary tip and followed by their return to the cell body. The outward or anterograde movement is powered by kinesin-2 while the inward or retrograde movement is powered by cytoplasmic dynein 2/1b. The IFT particles are composed of
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| - Transporte intraflagelar (es)
- Intraflagellar transport (en)
- Интрафлагеллярный транспорт (ru)
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| - El Transporte intraflagelar o IFT (por sus siglas en inglés Intraflagellar transport) es un proceso celular esencial para la formación y el mantenimiento de los cilios y flagelos eucariotas. Fue descubierto por primera vez en 1993 por el estudiante de grado Keith Kozminski cuando se encontraba trabajando en el laboratorio de en la Universidad de Yale. Es una estructura filogenéticamente bien conservada y parece que está presente en los cilios y flagelos de la mayor parte de las especies, siendo la excepción algunos apicomplejos como Plasmodium falciparum o Cryptosporidium parvum. El proceso ha sido bien caracterizado en el alga biflagelada Chlamydomonas reinhardtii, así como en los cilios sensoriales del nemátodo Caenorhabditis elegans. (es)
- Интрафлагеллярный транспорт (ИФТ; англ. Intraflagellar transport, IFT) — специализированный вид , ответственный за образование и поддержание структуры и функций цилий. (ru)
- Intraflagellar transport (IFT) is a bidirectional motility along axoneme microtubules that is essential for the formation (ciliogenesis) and maintenance of most eukaryotic cilia and flagella. It is thought to be required to build all cilia that assemble within a membrane projection from the cell surface. Plasmodium falciparum cilia and the sperm flagella of Drosophila are examples of cilia that assemble in the cytoplasm and do not require IFT. The process of IFT involves movement of large protein complexes called IFT particles or trains from the cell body to the ciliary tip and followed by their return to the cell body. The outward or anterograde movement is powered by kinesin-2 while the inward or retrograde movement is powered by cytoplasmic dynein 2/1b. The IFT particles are composed of (en)
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| - Intraflagellar transport (IFT) is a bidirectional motility along axoneme microtubules that is essential for the formation (ciliogenesis) and maintenance of most eukaryotic cilia and flagella. It is thought to be required to build all cilia that assemble within a membrane projection from the cell surface. Plasmodium falciparum cilia and the sperm flagella of Drosophila are examples of cilia that assemble in the cytoplasm and do not require IFT. The process of IFT involves movement of large protein complexes called IFT particles or trains from the cell body to the ciliary tip and followed by their return to the cell body. The outward or anterograde movement is powered by kinesin-2 while the inward or retrograde movement is powered by cytoplasmic dynein 2/1b. The IFT particles are composed of about 20 proteins organized in two subcomplexes called complex A and B. IFT was first reported in 1993 by graduate student Keith Kozminski while working in the lab of Dr. Joel Rosenbaum at Yale University. The process of IFT has been best characterized in the biflagellate alga Chlamydomonas reinhardtii as well as the sensory cilia of the nematode Caenorhabditis elegans. It has been suggested based on localization studies that IFT proteins also function outside of cilia. (en)
- El Transporte intraflagelar o IFT (por sus siglas en inglés Intraflagellar transport) es un proceso celular esencial para la formación y el mantenimiento de los cilios y flagelos eucariotas. Fue descubierto por primera vez en 1993 por el estudiante de grado Keith Kozminski cuando se encontraba trabajando en el laboratorio de en la Universidad de Yale. Es una estructura filogenéticamente bien conservada y parece que está presente en los cilios y flagelos de la mayor parte de las especies, siendo la excepción algunos apicomplejos como Plasmodium falciparum o Cryptosporidium parvum. El proceso ha sido bien caracterizado en el alga biflagelada Chlamydomonas reinhardtii, así como en los cilios sensoriales del nemátodo Caenorhabditis elegans. (es)
- Интрафлагеллярный транспорт (ИФТ; англ. Intraflagellar transport, IFT) — специализированный вид , ответственный за образование и поддержание структуры и функций цилий. (ru)
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