About: IgA specific serine endopeptidase

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IgA protease (EC 3.4.21.72, IgA-specific serine endopeptidase, IgA proteinase, IgA-specific proteinase, immunoglobulin A protease, immunoglobulin A proteinase) is an enzyme. This enzyme catalyses the following chemical reaction[reaction equation needed] It performs cleavage of immunoglobulin A molecules at certain Pro- bonds in the hinge region. No small molecule substrates are known This enzyme is secreted by Gram-negative bacteria Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, and Gram-positive Streptococcus pneumoniae.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Enzyme yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 enzyme protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459
rdfs:label	IgA specific serine endopeptidase (en)
rdfs:comment	IgA protease (EC 3.4.21.72, IgA-specific serine endopeptidase, IgA proteinase, IgA-specific proteinase, immunoglobulin A protease, immunoglobulin A proteinase) is an enzyme. This enzyme catalyses the following chemical reaction[reaction equation needed] It performs cleavage of immunoglobulin A molecules at certain Pro- bonds in the hinge region. No small molecule substrates are known This enzyme is secreted by Gram-negative bacteria Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, and Gram-positive Streptococcus pneumoniae. (en)
foaf:name	IgA-specific serine endopeptidase (en)
name	IgA-specific serine endopeptidase (en)
dcterms:subject	EC 3.4.21 Proteases
Wikipage page ID	35532232 (xsd:integer)
Wikipage revision ID	1113674254 (xsd:integer)
Link from a Wikipage to another Wikipage	Proline Chemical reaction Enzyme Haemophilus influenzae Bacteria Threonine Gram-positive Alanine Amino acid Gram-negative bacteria Streptococcus pneumoniae Arginine EC 3.4.21 Proteases Catalyst Serine Neisseria gonorrhoeae Neisseria meningitidis Immunoglobulin A
sameAs	IgA specific serine endopeptidase IgA specific serine endopeptidase IgA specific serine endopeptidase IgA specific serine endopeptidase IgA specific serine endopeptidase
dbp:wikiPageUsesTemplate	dbt:EC_number dbt:Enzymes dbt:Infobox_enzyme dbt:MeshName dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:Serine_endopeptidases
CAS number	55127 (xsd:integer)
EC number	3.400000 (xsd:double)
IUBMB EC number	3 (xsd:integer)
has abstract	IgA protease (EC 3.4.21.72, IgA-specific serine endopeptidase, IgA proteinase, IgA-specific proteinase, immunoglobulin A protease, immunoglobulin A proteinase) is an enzyme. This enzyme catalyses the following chemical reaction[reaction equation needed] It performs cleavage of immunoglobulin A molecules at certain Pro- bonds in the hinge region. No small molecule substrates are known This enzyme is secreted by Gram-negative bacteria Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, and Gram-positive Streptococcus pneumoniae. The action of IgA protease allows the above mentioned bacteria to adhere to mucous membranes. An IgA protease is a highly specific 106kDa enzyme that cleaves amino acid sequences of certain proteins. The natural substrate of IgA proteases is immunoglobulin A, hence its name. The enzyme is in fact capable of cleavage of proteins with the amino acid sequence Cleaves N-X-Z-Pro-Pro/-Y-Pro-C, where the X in the sequence preferably is a Proline or Serine; the Y = Threonine, Serine or Alanine; and Z preferably is Arginine or Threonine. Because of the sequence that the enzyme is able to cleave, it is also called IgAse Pro-Pro-Y-Pro. Thus, the IgA protease act by cleaving the proline-rich hinge region of the heavy chain of IgA1. Three major bacteria, Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type B, release the IgA protease which destroys IgA. (en)
gold:hypernym	Enzyme
prov:wasDerivedFrom	wikipedia-en:IgA_specific_serine_endopeptidase?oldid=1113674254&ns=0
page length (characters) of wiki page	3095 (xsd:nonNegativeInteger)
EC number	3.4.21.72
foaf:isPrimaryTopicOf	wikipedia-en:IgA_specific_serine_endopeptidase
is Link from a Wikipage to another Wikipage of	PA clan of proteases IgA protease Immunoglobulin A IgA-specific serine endopeptidase
is Wikipage redirect of	IgA-specific serine endopeptidase
is foaf:primaryTopic of	wikipedia-en:IgA_specific_serine_endopeptidase

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