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About: Hovlinc     Goto   Sponge   NotDistinct   Permalink

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Hovlinc RNA is a self-cleaving ribozyme of about 168 nucleotides found in a very long noncoding RNA (vlincRNA) in humans, chimpanzees, and gorillas. The word "hovlinc" comes from "hominin vlincRNA-located" RNA. Hovlinc is only a fourth known case of a ribozyme in human. Self-cleavage activity of Hovlinc has been shown in human, chimpanzees and bonobos, but is absent in gorillas, raising questions about Hovlinc's biological function and evolution.