The Heart Research Institute (HRI) is a not-for-profit research facility, originally based in Camperdown, New South Wales, Australia and currently based in Newtown, New South Wales. Established in 1989 through a joint initiative of the National Heart Foundation of Australia, the cardiologists of Royal Prince Alfred Hospital, the Government of Australia, and Government of New South Wales, the Institute has become a research and research training facility, in particular in investigating the disease atherosclerosis.