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About: HU-331     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatPhenols, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:Abstraction100002137yago:Agent114778436yago:Alcohol107884567yago:Beverage107881800yago:CausalAgent100007347yago:Chemical114806838yago:Compound114818238yago:Drug103247620yago:DrugOfAbuse103248958yago:Fluid114939900yago:Food100021265yago:Liquid114940386yago:Material114580897yago:Matter100020827yago:OrganicCompound114727670yago:Part113809207yago:Phenol114989545yago:PhysicalEntity100001930yago:Relation100031921chemical compounddrugyago:Substance100019613yago:Substance100020090yago:WikicatAlcoholsyago:WikicatPhenols New Facet based on Instances of this Class

HU-331 is a quinone anticarcinogenic drug synthesized from cannabidiol, a cannabinoid in the Cannabis sativa plant. It showed a great efficacy against oncogenic human cells. HU-331 does not cause arrest in cell cycle, cell apoptosis or caspase activation. HU-331 inhibits DNA topoisomerase II even at nanomolar concentrations, but has shown a negligible effect on the action of DNA topoisomerase I. The cannabinoid quinone HU-331 is a very specific inhibitor of topoisomerase II, compared with most known anticancer quinones. One of the main objectives of these studies is the development of a new quinone derived compound that produces anti-neoplastic activity while maintaining low toxicity at therapeutic doses.