About: HIF prolyl-hydroxylase inhibitor

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Not to be confused with Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors Hypoxia-inducible factor prolyl hydroxylase Inhibitors (HIF-PHIs) also known as hypoxia-inducible factor stabilizers (HIF stabilizers) are members of a mostly experimental class of drugs that act by inhibiting hypoxia-inducible factor-proline dioxygenase (HIF prolyl-hydroxylase) which is responsible to break down the hypoxia-inducible factor (HIF) under conditions of normal oxygen concentrations.

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rdf:type	yago:Agent114778436 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:PhysicalEntity100001930 yago:Substance100020090 yago:WikicatDrugs
rdfs:label	HIF prolyl-hydroxylase inhibitor (en) HIF-PH阻害剤 (ja)
rdfs:comment	HIF-PH阻害剤（HIF-PHそがいざい、低酸素誘導因子プロリン水酸化酵素阻害剤、hypoxia-inducible factor prolyl-hydroxylase inhibitor）は、低酸素誘導因子安定化剤（HIF安定化剤）としても知られ、低酸素誘導因子（HIF）の分解に関与するという酵素を阻害することによって作用する、新しい種類の薬剤である。 2008年現在、貧血や慢性腎臓病、がん、心筋組織への影響などが研究されている。マウスで行われた研究では、エリスロポエチンの発現を増加させることにより、海馬の記憶を増加させる可能性があることを示唆している。 (ja) Not to be confused with Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors Hypoxia-inducible factor prolyl hydroxylase Inhibitors (HIF-PHIs) also known as hypoxia-inducible factor stabilizers (HIF stabilizers) are members of a mostly experimental class of drugs that act by inhibiting hypoxia-inducible factor-proline dioxygenase (HIF prolyl-hydroxylase) which is responsible to break down the hypoxia-inducible factor (HIF) under conditions of normal oxygen concentrations. (en)
foaf:depiction
dcterms:subject	Enzyme inhibitors
Wikipage page ID	22859273 (xsd:integer)
Wikipage revision ID	1068588248 (xsd:integer)
Link from a Wikipage to another Wikipage	Enarodustat Enzyme inhibitor Hypoxia-inducible factor Desidustat In vitro Anemia Daprodustat dbr:Erythropoietin Chronic kidney disease Hippocampus Enzyme inhibitors Ischemia Hypoxia-inducible factor-proline dioxygenase HIF prolyl-hydroxylase Hypoxia-inducible factors Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors Roxadustat Molidustat Vadadustat
sameAs	HIF prolyl-hydroxylase inhibitor HIF prolyl-hydroxylase inhibitor HIF prolyl-hydroxylase inhibitor HIF prolyl-hydroxylase inhibitor HIF prolyl-hydroxylase inhibitor
dbp:wikiPageUsesTemplate	dbt:Infobox_drug_class dbt:As_of dbt:Reflist dbt:Unreliable_source%3F dbt:Blood-drug-stub
thumbnail	wiki-commons:Special:FilePath/Roxadustat.svg?width=300
ATC prefix	B03X (en)
caption	Roxadustat, the first marketed HIF prolyl-hydroxylase inhibitor (en)
has abstract	Not to be confused with Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors Hypoxia-inducible factor prolyl hydroxylase Inhibitors (HIF-PHIs) also known as hypoxia-inducible factor stabilizers (HIF stabilizers) are members of a mostly experimental class of drugs that act by inhibiting hypoxia-inducible factor-proline dioxygenase (HIF prolyl-hydroxylase) which is responsible to break down the hypoxia-inducible factor (HIF) under conditions of normal oxygen concentrations. As of 2008 they had been investigated in in cell models for the treatment of anemia, chronic kidney disease (CKD), ischemia including ischemia of the heart tissue, cancer, and others.Research conducted in mice suggests that they may increase hippocampal memory by increasing erythropoietin expression. As of 2021 research focuses mainly on anemia associated with CKD, and to some extent on ischemia. One drug of this class (roxadustat) is marketed in China and Japan for the treatment of anaemia in CKD patients. (en) HIF-PH阻害剤（HIF-PHそがいざい、低酸素誘導因子プロリン水酸化酵素阻害剤、hypoxia-inducible factor prolyl-hydroxylase inhibitor）は、低酸素誘導因子安定化剤（HIF安定化剤）としても知られ、低酸素誘導因子（HIF）の分解に関与するという酵素を阻害することによって作用する、新しい種類の薬剤である。 2008年現在、貧血や慢性腎臓病、がん、心筋組織への影響などが研究されている。マウスで行われた研究では、エリスロポエチンの発現を増加させることにより、海馬の記憶を増加させる可能性があることを示唆している。 (ja)
Biological target	HIF prolyl-hydroxylase
Mechanism of action	Enzyme inhibitor
gold:hypernym	Members
prov:wasDerivedFrom	wikipedia-en:HIF_prolyl-hydroxylase_inhibitor?oldid=1068588248&ns=0
page length (characters) of wiki page	5544 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:HIF_prolyl-hydroxylase_inhibitor
is Link from a Wikipage to another Wikipage of	Carlos Oyarzun Enarodustat List of doping cases in athletics List of doping cases in cycling Procollagen-proline dioxygenase Hypoxia-inducible factor Bertrand Moulinet Desidustat Daprodustat Fabio Taborre Java–Partizan Pro Cycling Team Hypoxia-inducible factor-proline dioxygenase HIF-PHI HIF stabilizer Hypoxia-inducible factor prolyl hydroxylase Inhibitor Hypoxia-inducible factor stabilizer Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors Roxadustat Molidustat Vadadustat
is Wikipage redirect of	HIF-PHI HIF stabilizer Hypoxia-inducible factor prolyl hydroxylase Inhibitor Hypoxia-inducible factor stabilizer
is foaf:primaryTopic of	wikipedia-en:HIF_prolyl-hydroxylase_inhibitor

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