German submarine U-376 was a Type VIIC U-boat of Nazi Germany's Kriegsmarine during World War II. The submarine was laid down on 3 April 1940 in Kiel, launched on 10 July 1941, and commissioned on 21 August 1941 under the command of Oberleutnant zur See Friedrich-Karl Marks. U-376 was attached to the 6th U-boat Flotilla, and was ready for front-line service from 1 March 1942. Operating from Norwegian bases, from 1 July 1942 she served with the 11th U-boat Flotilla, and was transferred to the 3rd U-boat Flotilla, based in France on 1 March 1943.