About: Gating (electrophysiology)

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In electrophysiology, the term gating refers to the opening (activation) or closing (by deactivation or inactivation) of ion channels. This change in conformation is a response to changes in transmembrane voltage. These voltage-dependent changes in function are critical for a large number of processes in excitable and nonexcitable cells.

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rdfs:label	Gating (electrophysiology) (en)
rdfs:comment	In electrophysiology, the term gating refers to the opening (activation) or closing (by deactivation or inactivation) of ion channels. This change in conformation is a response to changes in transmembrane voltage. These voltage-dependent changes in function are critical for a large number of processes in excitable and nonexcitable cells. (en)
foaf:depiction
dcterms:subject	Electrophysiology Ion channels Cell communication
Wikipage page ID	23965432 (xsd:integer)
Wikipage revision ID	1105418203 (xsd:integer)
Link from a Wikipage to another Wikipage	Electrophysiology Cytoplasm Depolarization Electrostatic forces Ligand-gated ion channel Electrophysiology Membrane potential Permeability (electromagnetism) Poisson's equation Action potential Activation Cellular organization G protein Ion channels Ball and chain inactivation Cell membrane Kinetics (physics) Synaptic gating Ion channels Cell communication Phosphate Voltage-gated ion channel Phosphorylation Synaptic potential
sameAs	Gating (electrophysiology) Gating (electrophysiology) Gating (electrophysiology) Gating (electrophysiology)
dbp:wikiPageUsesTemplate	dbt:Dubious dbt:Reflist
thumbnail	wiki-commons:Special:FilePath/PDB_1av2_EBI.jpg?width=300
date	November 2018 (en)
reason	Only K channels, not Na or Ca, have four separate subunits. (en)
has abstract	In electrophysiology, the term gating refers to the opening (activation) or closing (by deactivation or inactivation) of ion channels. This change in conformation is a response to changes in transmembrane voltage. When ion channels are in a 'closed' (non-conducting) state, they are impermeable to ions and do not conduct electrical current. When ion channels are in their open state, they conduct electrical current by allowing specific types of ions to pass through them, and thus, across the plasma membrane of the cell. Gating is the process by which an ion channel transitions between its open and closed states. A variety of cellular changes can trigger gating, depending on the ion channel, including changes in voltage across the cell membrane (voltage-gated ion channels), chemicals interacting with the ion channel (ligand-gated ion channels), changes in temperature, stretching or deformation of the cell membrane, addition of a phosphate group to the ion channel (phosphorylation), and interaction with other molecules in the cell (e.g., G proteins). The rate at which any of these gating processes occurs in response to these triggers are known as the kinetics of gating. Some drugs and many ion channel toxins act as 'gating modifiers' of voltage-gated ion channels by changing the kinetics of gating. The voltage-gated ion channels of the action potential are often described as having four gating processes: activation, deactivation, inactivation, and reactivation (also called 'recovery from inactivation'). Activation is the process of opening the activation gate, which occurs in response to the voltage inside the cell membrane (the membrane potential) becoming more positive with respect to the outside of the cell (depolarization), and 'deactivation' is the opposite process of the activation gate closing in response to the inside of the membrane becoming more negative (repolarization). 'Inactivation' is the closing of the inactivation gate, and occurs in response to the voltage inside the membrane becoming more positive, but more slowly than activation. 'Reactivation' is the opposite of inactivation, and is the process of reopening the inactivation gate. These voltage-dependent changes in function are critical for a large number of processes in excitable and nonexcitable cells. (en)
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is Link from a Wikipage to another Wikipage of	dbr:Cystic_fibrosis_transmembrane_conductance_regulator Index of biophysics articles Ligand-gated ion channel Potassium channel BotIT2 Tertiapin Aquaporin Action potential Ion channel Discovery and development of TRPV1 antagonists Graphene lens KcsA potassium channel Gating Hyperpolarization (biology) Jingzhaotoxin Heteropodatoxin Hodgkin cycle Voltage sensitive phosphatase Phrixotoxin P-type calcium channel P2X purinoreceptor
is Wikipage disambiguates of	Gating
is foaf:primaryTopic of	wikipedia-en:Gating_(electrophysiology)

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