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About: GTS-21     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatStimulantsyago:Abstraction100002137yago:Base114618253yago:Chemical114806838yago:Cognition100023271yago:Compound114818238yago:Element114840755yago:Information105816287yago:Material114580897yago:Matter100020827yago:Part113809207yago:PhysicalEntity100001930yago:PsychologicalFeature100023100yago:Pyridine114692510yago:Quintessence114847103yago:Relation100031921drugyago:Stimulation105827684yago:Substance100019613yago:WikicatPhenolEthersyago:WikicatPyridinesumbel-rc:DrugProduct New Facet based on Instances of this Class

GTS-21 (DMXBA) is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent. Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21 display nootropic and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease, nicotine dependence, and, most significantly, for schizophrenia.