Frank Henderson Mayfield (June 23, 1908 – January 2, 1991), was an American neurosurgeon and founder of the Mayfield Clinic and Spine Institute in Cincinnati, Ohio. A pioneer in brain and spine surgery, he invented the spring aneurysm clip and the Mayfield skull clamp. Mayfield is best known for his clinical interests in peripheral nerve and spine injuries, development of neurosurgical instruments, and medical politics.