The theory of facilitated variation demonstrates how seemingly complex biological systems can arise through a limited number of regulatory genetic changes, through the differential re-use of pre-existing developmental components. The theory was presented in 2005 by Marc W. Kirschner (a professor and chair at the Department of Systems Biology, Harvard Medical School) and John C. Gerhart (a professor at the Graduate School, University of California, Berkeley).
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| - Erleichterte Variation (de)
- Facilitated variation (en)
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| - Die Theorie der erleichterten Variation (engl.: Theory of Facilitated Variation) ist ein Erklärungsmodell, das sich als Ergänzung der Evolutionstheorie versteht und sich mit der Beschaffenheit der Variation in der Evolution befasst. Diese Theorie wurde im Jahr 2005 von Marc Kirschner, Gründer und Vorsitzender des Fachbereichs Systems Biology der Harvard Medical School, und , Professor an der University of California, Berkeley, in ihrem Buch The Plausibility of Life veröffentlicht (deutscher Titel: Die Lösung von Darwins Dilemma). (de)
- The theory of facilitated variation demonstrates how seemingly complex biological systems can arise through a limited number of regulatory genetic changes, through the differential re-use of pre-existing developmental components. The theory was presented in 2005 by Marc W. Kirschner (a professor and chair at the Department of Systems Biology, Harvard Medical School) and John C. Gerhart (a professor at the Graduate School, University of California, Berkeley). (en)
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| - The theory of facilitated variation demonstrates how seemingly complex biological systems can arise through a limited number of regulatory genetic changes, through the differential re-use of pre-existing developmental components. The theory was presented in 2005 by Marc W. Kirschner (a professor and chair at the Department of Systems Biology, Harvard Medical School) and John C. Gerhart (a professor at the Graduate School, University of California, Berkeley). The theory of facilitated variation addresses the nature and function of phenotypic variation in evolution. Recent advances in cellular and evolutionary developmental biology shed light on a number of mechanisms for generating novelty. Most anatomical and physiological traits that have evolved since the Cambrian are, according to Kirschner and Gerhart, the result of regulatory changes in the usage of various conserved core components that function in development and physiology. Novel traits arise as novel packages of modular core components, which requires modest genetic change in regulatory elements. The modularity and adaptability of developmental systems reduces the number of regulatory changes needed to generate adaptive phenotypic variation, increases the probability that genetic mutation will be viable, and allows organisms to respond flexibly to novel environments. In this manner, the conserved core processes facilitate the generation of adaptive phenotypic variation, which natural selection subsequently propagates. (en)
- Die Theorie der erleichterten Variation (engl.: Theory of Facilitated Variation) ist ein Erklärungsmodell, das sich als Ergänzung der Evolutionstheorie versteht und sich mit der Beschaffenheit der Variation in der Evolution befasst. Diese Theorie wurde im Jahr 2005 von Marc Kirschner, Gründer und Vorsitzender des Fachbereichs Systems Biology der Harvard Medical School, und , Professor an der University of California, Berkeley, in ihrem Buch The Plausibility of Life veröffentlicht (deutscher Titel: Die Lösung von Darwins Dilemma). (de)
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