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The Evolutionary Classification of Protein Domains (ECOD) is a biological database that classifies protein domains available from the Protein Data Bank. The ECOD tries to determine the evolutionary relationships between proteins. Similar to Pfam, CATH, and SCOP, ECOD compiles domains instead of whole proteins. However, ECOD focuses on evolutionary relationships more heavily: instead of grouping proteins by folds, which may simply represent convergent evolution, ECOD groups proteins by demonstratable homology only.

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  • Evolutionary Classification of Protein Domains (en)
  • タンパク質ドメイン進化的分類データベース (ja)
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  • The Evolutionary Classification of Protein Domains (ECOD) is a biological database that classifies protein domains available from the Protein Data Bank. The ECOD tries to determine the evolutionary relationships between proteins. Similar to Pfam, CATH, and SCOP, ECOD compiles domains instead of whole proteins. However, ECOD focuses on evolutionary relationships more heavily: instead of grouping proteins by folds, which may simply represent convergent evolution, ECOD groups proteins by demonstratable homology only. (en)
  • タンパク質ドメイン進化的分類(タンパクしつドメインしんかてきぶんるい、英: Evolutionary Classification of Protein Domains、ECOD)は、蛋白質構造データバンク(PDB)から入手可能なタンパク質ドメインを分類したである。ECODは、タンパク質間の進化的関係を決定しようとするものである。 ECODは、Pfam、CATH、SCOPと同様に、タンパク質全体ではなくドメインを収集する。ただし、ECODは進化的関係に重点を置いている。ECODでは、単純に収斂進化を示す可能性のあるフォールドによってタンパク質を分類するのではなく、実証可能な相同性のみによってタンパク質を分類している。 (ja)
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author
  • H. Cheng, R. D. Schaeffer, Y. Liao, L. N. Kinch, J. Pei, S. Shi, B. H. Kim, N. V. Grishin. (en)
released
scope
  • Protein domains (en)
title
  • ECOD (en)
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  • continuously updated (en)
Center
  • Grishin Lab, University of Texas Southwestern Medical Center (en)
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  • The Evolutionary Classification of Protein Domains (ECOD) is a biological database that classifies protein domains available from the Protein Data Bank. The ECOD tries to determine the evolutionary relationships between proteins. Similar to Pfam, CATH, and SCOP, ECOD compiles domains instead of whole proteins. However, ECOD focuses on evolutionary relationships more heavily: instead of grouping proteins by folds, which may simply represent convergent evolution, ECOD groups proteins by demonstratable homology only. (en)
  • タンパク質ドメイン進化的分類(タンパクしつドメインしんかてきぶんるい、英: Evolutionary Classification of Protein Domains、ECOD)は、蛋白質構造データバンク(PDB)から入手可能なタンパク質ドメインを分類したである。ECODは、タンパク質間の進化的関係を決定しようとするものである。 ECODは、Pfam、CATH、SCOPと同様に、タンパク質全体ではなくドメインを収集する。ただし、ECODは進化的関係に重点を置いている。ECODでは、単純に収斂進化を示す可能性のあるフォールドによってタンパク質を分類するのではなく、実証可能な相同性のみによってタンパク質を分類している。 (ja)
curation
  • manual for new proteins; automated for ones with close matches (en)
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  • ECOD (en)
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