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ELMO (Engulfment and Cell Motility) is a family of related proteins (~82 kDa) involved in intracellular signalling networks. These proteins have no intrinsic catalytic activity and instead function as adaptors which can regulate the activity of other proteins through their ability to mediate protein-protein interactions. This family contains members in all animals. In humans there are three paralogous isoforms: * ELMO1 * ELMO2 * ELMO3

AttributesValues
rdf:type
rdfs:label
  • ELMO (protein) (en)
  • ELMO (蛋白质) (zh)
rdfs:comment
  • ELMO（英語：Engulfment and Cell Motility的缩写）是一个涉及细胞內信号传送的蛋白质家族，大小约 82 kDa。这类蛋白质并没有生物催化活性，而是以蛋白質交互作用起到信号转导接头蛋白的作用。 几乎所有动物基因组中都有这一家族蛋白，在人类基因组中，有三个旁系同源体： * * * 最早发现的ELMO蛋白是来自于秀麗隱桿線蟲（Caenorhabditis elegans）的CED-12。 (zh)
  • ELMO (Engulfment and Cell Motility) is a family of related proteins (~82 kDa) involved in intracellular signalling networks. These proteins have no intrinsic catalytic activity and instead function as adaptors which can regulate the activity of other proteins through their ability to mediate protein-protein interactions. This family contains members in all animals. In humans there are three paralogous isoforms: * ELMO1 * ELMO2 * ELMO3 (en)
name
  • ELMO/CED-12 family (en)
dcterms:subject
Wikipage page ID
Wikipage revision ID
Link from a Wikipage to another Wikipage
sameAs
dbp:wikiPageUsesTemplate
PROSITE
  • PDOC51335 (en)
InterPro
  • IPR006816 (en)
Pfam
  • PF04727 (en)
symbol
  • ELMO_CED12 (en)
has abstract
  • ELMO (Engulfment and Cell Motility) is a family of related proteins (~82 kDa) involved in intracellular signalling networks. These proteins have no intrinsic catalytic activity and instead function as adaptors which can regulate the activity of other proteins through their ability to mediate protein-protein interactions. This family contains members in all animals. In humans there are three paralogous isoforms: * ELMO1 * ELMO2 * ELMO3 The ELMO domain was first characterized in the CED-12 proteins of Caenorhabditis elegans and Drosophila melanogaster, which is a homolog to the ELMO protein found in mammals. This protein is involved in Rac-GTPase activation, apoptotic cell phagocytosis, cell migration, and cytoskeletal rearrangements. (en)
  • ELMO（英語：Engulfment and Cell Motility的缩写）是一个涉及细胞內信号传送的蛋白质家族，大小约 82 kDa。这类蛋白质并没有生物催化活性，而是以蛋白質交互作用起到信号转导接头蛋白的作用。 几乎所有动物基因组中都有这一家族蛋白，在人类基因组中，有三个旁系同源体： * * * 最早发现的ELMO蛋白是来自于秀麗隱桿線蟲（Caenorhabditis elegans）的CED-12。 (zh)
gold:hypernym
prov:wasDerivedFrom
page length (characters) of wiki page
Symbol
  • ELMO_CED12
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