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About: Dotarizine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatCalciumChannelBlockersyago:WikicatMolecularFormulasyago:WikicatSerotoninAntagonistsyago:Abstraction100002137yago:Adversary109773245yago:Athlete109820263yago:Blocker109860248yago:CausalAgent100007347yago:Communication100033020yago:Contestant109613191yago:FootballPlayer110101634yago:Formula106816935yago:LivingThing100004258yago:Message106598915yago:MolecularFormula106817173yago:Object100002684yago:Organism100004475yago:Person100007846yago:PhysicalEntity100001930yago:Player110439851yago:YagoLegalActoryago:YagoLegalActorGeodrugyago:Statement106722453yago:Whole100003553umbel-rc:DrugProduct New Facet based on Instances of this Class

Dotarizine is a drug used in the treatment of migraine, which acts as a calcium channel blocker, and also as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A and 5HT2C receptors. The anti-migraine action is thought to be due to its action as a vasodilator, but it also has some anxiolytic effects and blocks amnesia produced by electroconvulsive shock in animals.