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Diclazepam (Ro5-3448), also known as chlorodiazepam and 2'-chloro-diazepam, is a benzodiazepine and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. It is not currently approved for use as a medication, but rather sold as an unscheduled substance. Efficacy and safety have not been tested in humans. In animal models, its effects are similar to diazepam, possessing long-acting anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties.

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  • Diclazepam (de)
  • Diclazepam (en)
  • Diclazepam (it)
  • Diclazépam (fr)
  • Diclazepam (pt)
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  • Diclazepam (2′-Chlordiazepam) ist eine chemische Verbindung aus der Gruppe der Benzodiazepine und wirkt analog zu Diazepam. (de)
  • Diclazepam (Ro5-3448), also known as chlorodiazepam and 2'-chloro-diazepam, is a benzodiazepine and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. It is not currently approved for use as a medication, but rather sold as an unscheduled substance. Efficacy and safety have not been tested in humans. In animal models, its effects are similar to diazepam, possessing long-acting anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties. (en)
  • Le diclazépam ou chlorodiazépam est un composé appartenant à la famille des benzodiazépines. Le diclazépam est la version du diazépam à laquelle on a ajouté un atome de chlore en R2'. C'est la version sans le groupe hydroxy du lorazépam en position 3. La présence d'un groupe méthyle au dessus de son cycle diazépine augmente son caractère lipophile comparé à son homologue, ce qui améliore son absorption dans le système nerveux et réduit son délai d'action, tout en augmentant quelque peu le risque d'effets secondaires notoires tels que l'amnésie. (fr)
  • Il diclazepam, conosciuto anche come clorodiazepam o 2-clorodiazepam è uno psicofarmaco della categoria delle benzodiazepine ed è molto simile come funzioni al Diazepam; viene commercializzato da Hoffmann-La Roche di Basilea dal 1960. È stato sintetizzato dal chimico Leo Sternbach. (it)
  • Diclazepam (Ro5-3448), também conhecido como clorodiazepam e 2'-cloro-diazepam, é um benzodiazepínico e análogo funcional do diazepam. Foi sintetizado pela primeira vez por Leo Sternbach e sua equipe no Hoffman-La Roche em 1960. Atualmente não está aprovado para uso como medicamento. A eficácia e segurança não foram testadas em humanos. Em testes com animais, seus efeitos são semelhantes aos do diazepam, possuindo propriedades de longa ação ansiolíticas, anticonvulsivantes, hipnóticas, sedativas, relaxantes musculo-esqueléticas e amnésicas. (pt)
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